Distribution of High-Risk Human Papillomavirus Genotypes among Women with Colposcopic Diagnosis of Cervical Intraepithelial Neoplasia in Bangladesh

Background: The incidence of cervical cancer is high in Bangladesh and there a prevalence preinvasive lower genital tract disease among women reproductive age. Persistent high-risk Human Papilloma Virus (HPV) infection the main underlying cause its precursor, intraepithelial neoplasia (CIN). Objective: aim study was to identify subtypes HPV with colposcopic diagnosis Bangladesh. Methods: This cross-sectional observational conducted colposcopy clinic Dhaka Medical College Hospital over six-month period. A total 100 participants were enrolled. Married women, between 30 - 60 years age colposcopically diagnosed intra epithelial Women chronic illness, pregnancy, unable consent excluded from this study. After counselling, directed punch biopsies taken each CIN case concurrently testing by polymerase chain reaction (PCR). Results: mean patients 38.69 (SD ±7.76) years. 1 57% participants, while 24% had II 19% III lesions. High-risk present 52 patients. 16 most common identified 28 (53.84%) 18 second 20 (38.46%) either singly or combination other subtypes. strains, 31, 33, 35, 52, 56 58, also detected as mono co-infections. Out positive cases, 29 (55.8%) 23 (44.2%) co-infection several highest (50%) oncogenic infections aged 35 45 Risk factors associated cases parity (P 0.05), early at marriage = 0.754) first child. Conclusion: genotypes. vaccination current 9-valent vaccine, which contains types 6, 11, 16, 18, 45, 58. Will be an effective public health measure eradicate